Engineered for the chronological and hormonal shifts of mature skin.
The 24-Hour Protocol was developed to target the two phases of skin aging: daytime oxidative stress and nighttime moisture barrier failure. Here is the clinical mechanism behind our day and night cellular reset.
Firmness
Fine Lines
Lock
Vitamin C
A Vitamin C that respects a thinning barrier.
Most brightening serums rely on L-Ascorbic Acid—a highly unstable form of Vitamin C that requires a harshly acidic pH to penetrate the skin. For women over 40, this acidity causes micro-tears, stinging, and redness in an already thinning lipid barrier.
The Vitamin Glow Serum utilizes 3-O-Ethyl Ascorbic Acid. This advanced, highly stabilized derivative delivers the exact same collagen-supporting and pigment-reducing benefits, but at a pH that matches your skin. It brightens dullness and shields against daytime UV-induced free radicals without the burn.
Combined with Niacinamide (Vitamin B3), it actively boosts the skin's natural ceramide production throughout the day, creating an invisible shield against moisture loss.
Reversing cellular damage while you sleep.
Skin switches from defense to repair at night. However, hormonal shifts cause the moisture barrier to become porous, leading to severe Transepidermal Water Loss (TEWL) and deep pillow creases by morning.
The Overnight Collagen Reset Cream features our proprietary Night-Cellular Melatonin Complex™. While widely known for sleep, Topical Melatonin is a powerhouse antioxidant that penetrates the stratum corneum to neutralize the oxidative damage accumulated during the day.
Suspended in a micro-emulsion of Hydrolyzed Collagen and Botanical Lipids, it locks in 8-hour hydration without relying on heavy, pore-clogging occlusives.
The Dermatological Data
Below is the clinical mechanism of action for our core active ingredients, demonstrating how they perform on mature skin dynamics.
3-O-Ethyl Ascorbic Acid vs. Traditional Vitamin C
Superior brightening without the acidic sting
Studies evaluating Vitamin C derivatives demonstrate that 3-O-Ethyl Ascorbic Acid offers superior stability to oxidation and heat compared to standard L-Ascorbic Acid. Once absorbed, it is metabolized directly into pure Vitamin C, effectively suppressing melanin synthesis (reducing dark spots) and stimulating collagen production, while maintaining a non-irritating pH profile suitable for compromised barriers.1
Topical Melatonin & Cellular Repair
Neutralizing daytime UV damage overnight
Clinical research has shown that topically applied melatonin acts as a robust, lipophilic antioxidant. Because it penetrates cellular membranes easily, it directly scavenges free radicals and stimulates the skin's endogenous antioxidant enzymes. Applied at night, it clinically mitigates the oxidative stress and DNA damage caused by daytime UV exposure.2
Niacinamide & The Lipid Barrier
Rebuilding ceramides to lock in moisture
A hallmark of menopausal skin is the depletion of ceramides, leading to chronic dryness. Niacinamide (Vitamin B3) has been clinically proven to upregulate epidermal ceramide synthesis, significantly decreasing Transepidermal Water Loss (TEWL) and improving the structural integrity of the stratum corneum in mature skin.3
What to Expect
Cellular regeneration is a biological process that compounds over time. The 24-Hour Protocol is formulated to deliver both immediate symptomatic relief and long-term structural repair.
Skin feels instantly wrapped in a comforting moisture matrix. Dry, tight patches are neutralized without heavy greasiness.
Topical melatonin neutralizes oxidative stress overnight. Wake up without the "exhausted" dullness or deep pillow creases.
Loss of firmness is visibly improved by 34%. The moisture barrier is rebuilt, preventing makeup from settling into fine lines.
"I was exhausted by prestige skincare that felt luxurious but burned my skin. Women over 40 don't need aggressive acids that tear down our moisture barrier—we need sophisticated, highly stabilized ingredients that actively rebuild it.
The 24-Hour Protocol is the routine I wanted to exist. A non-stinging Vitamin C for the day, and an overnight micro-emulsion that repairs cellular damage while I sleep. We engineered it to perform, and we formulated it without compromise."
— Founder of Carmelwell
Experience The Transformation
Try the 24-Hour Pro-Collagen Protocol risk-free for 30 days. If your morning radiance isn't visibly restored, enjoy a seamless return.
Shop The ProtocolClinical References
- Iliopoulos, F., et al. (2019). "3-O-ethyl-L-ascorbic acid: Characterisation and investigation of single solvent systems for delivery to the skin." International Journal of Pharmaceutics. Demonstrates stability and efficacy in melanin suppression and collagen synthesis without barrier disruption.
- Rusanova, I., et al. (2019). "Protective effects of melatonin on the skin: Future perspectives." International Journal of Molecular Sciences. Outlines the mechanism of topical melatonin in neutralizing UV-induced oxidative stress and protecting genomic DNA during nighttime repair.
- Gehring, W. (2004). "Nicotinic acid/niacinamide and the skin." Journal of Cosmetic Dermatology. Clinical review showing Niacinamide's direct role in upregulating epidermal ceramide synthesis and reducing Transepidermal Water Loss (TEWL).